U.S. Code of Federal Regulations

Regulations most recently checked for updates: Aug 28, 2025

All TitlesTitle 21Chapter IPart 570Subpart E - Subpart E—Generally Recognized as Safe (GRAS) Notice
§ 570.203 - Definitions.
§ 570.205 - Opportunity to submit a GRAS notice.
§ 570.210 - How to send your GRAS notice to FDA.
§ 570.215 - Incorporation into a GRAS notice.
§ 570.220 - General requirements applicable to a GRAS notice.
§ 570.225 - Part 1 of a GRAS notice: Signed statements and certification.
§ 570.230 -
§ 570.235 - Part 3 of a GRAS notice: Target animal and human exposures.
§ 570.240 - Part 4 of a GRAS notice: Self-limiting levels of use.
§ 570.245 - Part 5 of a GRAS notice: Experience based on common use in food before 1958.
§ 570.250 - Part 6 of a GRAS notice: Narrative.
§ 570.255 - Part 7 of a GRAS notice: List of supporting data and information in your GRAS notice.
§ 570.260 - Steps you may take before FDA responds to your GRAS notice.
§ 570.265 - What FDA will do with a GRAS notice.
§ 570.275 - Public disclosure of a GRAS notice.
§ 570.280 - Submission of a supplement.
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